Sunday, January 6, 2008

Sunday January 6, 2008
Levaquin dosing in renal failure

Q; What's the dose adjustment of Levaquin (levofloxacin) in Hemodialysis or Chronic Ambulatory Peritoneal Dialysis (CAPD) as well as CVVHD patients?

A; For Hemodialysis, CAPD and with creatinine clearance less than 20 mL/min, dose of levofloxacin is 250 mg per 48 hours. In HD patients, dose should be given after HD session.

For CVVHD levaquin should be given as 250 mg/day as there is some clearance via CVVHD.

References: click to get abstract / article

1. Levaquin -
Pharmacokinetics of Levofloxacin and Ciprofloxacin during Continuous - Renal Replacement Therapy in Critically Ill Patients (pdf) - ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Oct. 2001, p. 2949–295

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